Translocation of a lysosomal enzyme across the microsomal membrane requires signal recognition particle.
نویسندگان
چکیده
Signal recognition particle (SRP), an 11S ribonucleoprotein (Walter and Blobel (1982) Nature 299, 691-698), is required for translocation of secretory proteins across microsomal membranes (Walter and Blobel (1980) Proc. Natl. Acad. Sci. USA 77, 7112-7116) and for asymmetric integration into microsomal membranes of a transmembrane protein (Anderson et al., (1982) J. Cell Biol. 93, 501-506). We demonstrate here that SRP is also required for translocation of the lysosomal protease cathepsin D across microsomal membranes.
منابع مشابه
Signal recognition particle: a ribonucleoprotein required for cotranslational translocation of proteins, isolation and properties.
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ورودعنوان ژورنال:
- Biochemical and biophysical research communications
دوره 115 1 شماره
صفحات -
تاریخ انتشار 1983